Keep track of Intently (two)pentobarbital will reduce the extent or impact of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Powerful CYP3A4 inducers may well lessen suvorexant efficacy; if improved suvorexant dose required, tend not to exceed 20 mg/working dayThe usage of barbiturates as sedatives